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Systemic, Digestive & Proteolytic Enzyme Supplements

Explore enzyme supplements including Vitalzym, Fibrenza, Neprinol, Devigest and other formulas. Compare ingredients, capsule formats, package sizes and label directions to find the product you are looking for.

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Compare Enzyme Supplement Types

Enzyme supplements come in different formulas and are not all used the same way. Compare the ingredient list, capsule format, serving size and label directions for the exact product you are considering.

Systemic Enzyme Formulas

Some enzyme products are marketed and labeled as systemic enzyme formulas. Product directions commonly distinguish them from meal-time digestive formulas, so follow the directions on the exact label you purchase.

Examples include Vitalzym, Fibrenza and Neprinol.

Digestive Enzyme Formulas

Digestive enzyme products commonly contain ingredients such as protease, amylase and lipase and are typically labeled for use with meals.

Devigest is one digestive-enzyme option available from Express Naturals.

Hybrid Enzyme Formulas

Some formulas contain multiple enzyme types and are described as hybrid systemic and digestive products. Serving size and timing can vary by formula.

Review each product’s Supplement Facts and label directions.

Specialty Enzyme & Nutrient Formulas

Some products combine enzymes with additional ingredients such as probiotics, prebiotics, vitamins, minerals or other nutrients.

Compare the complete ingredient panel rather than relying on the product name alone.

Common Enzymes Found in Supplements

Different products use different enzyme combinations. Ingredients you may see across the products in this category include:

  • Protease
  • Bromelain
  • Papain
  • Serrapeptase
  • Serratiopeptidase
  • Nattokinase
  • Amylase
  • Lipase

Ingredient amounts, enzyme activity units and serving sizes vary by product. Review the individual product page and current Supplement Facts label for exact information.

Shop Enzyme Supplements by Product Line

Vitalzym

Compare Vitalzym Original 450, Xe 180, Vitalzym 360 and Vitalzym Cardio 300 by count, capsule format, packaging, ingredients and label directions.

Fibrenza

Available in multiple bottle sizes with a multi-enzyme formula and delayed-release capsule technology.

Neprinol

Browse Neprinol products and review the individual formula, ingredient panel, count and label information.

Devigest

A digestive enzyme formula supplied as 90 capsules. Review the product page for its complete enzyme panel and directions.

Abzorb

A multi-ingredient formula containing digestive enzymes along with additional nutritional ingredients.

Compare Vitalzym Formulas

Use our Vitalzym comparison to review Original, Xe, 360 and Cardio side by side using objective product information.

What Are Proteolytic Enzymes?

Proteolytic enzymes are enzymes associated with proteins. Protease, bromelain, papain and serrapeptase are examples of proteolytic enzymes that appear in some of the formulas sold by Express Naturals.

Not every enzyme supplement contains the same proteolytic enzymes or the same amounts. Check the Supplement Facts panel of the exact formula you are comparing.

Comparing enzyme supplements? Start with objective differences: ingredient list, enzyme amounts or activity units, capsule format, bottle count, packaging, serving size and label directions.

For brand-level comparisons within Vitalzym, visit our Vitalzym enzyme supplements page.

How to Compare Enzyme Supplements

When reviewing different formulas, consider:

  • Which enzymes are listed on the Supplement Facts panel
  • Ingredient amounts or activity units
  • Capsule type and delivery format
  • Number of capsules per bottle or package
  • Serving size
  • Suggested-use and timing instructions
  • Other ingredients and dietary information

Because formulations differ, do not assume that two products with similar names or capsule counts contain equivalent formulas.

Buy Enzyme Supplements from EnzymeHub by Express Naturals

Express Naturals has specialized in enzyme supplements since 2006. Our selection includes Vitalzym, Fibrenza, Neprinol, digestive-enzyme products and other specialty formulas.

Enzyme Specialists Focused product selection and knowledgeable customer support.
Free U.S. Priority Shipping Free USPS Priority Mail shipping on orders within the United States.
30-Day Guarantee Qualifying opened or unopened products may be returned within 30 days of delivery.

Enzyme Supplements FAQ

What are enzyme supplements?

Enzyme supplements are products containing one or more enzymes. Formulas vary widely in their ingredients, serving sizes, capsule formats and label directions.

What is the difference between systemic and digestive enzyme supplements?

Digestive enzyme products are commonly labeled for use with meals. Products marketed as systemic enzyme formulas are commonly labeled differently, including directions that may specify taking them away from meals. Follow the directions on the exact product label.

What are proteolytic enzymes?

Proteolytic enzymes are enzymes associated with proteins. Examples appearing in products sold by Express Naturals include protease, bromelain, papain and serrapeptase.

Which enzyme products contain serrapeptase?

Serrapeptase or serratiopeptidase appears in several formulas sold by Express Naturals, including selected Vitalzym products. Review the individual product page and Supplement Facts panel because formulas vary.

Should enzyme supplements be taken with food?

It depends on the product. Some formulas are labeled for use with meals, while others have different timing instructions. Follow the directions printed on the current package of the exact product you purchase.

How do I choose between enzyme supplements?

Compare objective product information such as the ingredients, ingredient amounts or activity units, capsule format, package count, serving size and label directions.

Which brands are available from Express Naturals?

The current enzyme selection includes products from lines such as Vitalzym, Fibrenza, Neprinol and Devigest, along with other specialty formulas available on this page.

Can I use enzyme supplements with medications?

If you take prescription medication, are pregnant or nursing, are preparing for surgery or have questions about whether an enzyme supplement is appropriate for you, consult your healthcare professional and review the product label before use.

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

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