A preliminary trial of serrapeptase 
in patients with carpal tunnel syndrome.

Panagariya A, Sharma AK

Dept. of Neurology, SMS Medical College and Hospital, Jaipur.
J Assoc Physicians India 1999 Dec;47(12):1170-2

OBJECTIVES: This study was planned to assess the response of serrapeptase in patients with carpal tunnel syndrome (CTS). 

METHODS: Twenty patients with CTS were evaluated clinically. After baseline electrophysiological studies, these patients were given serrapetase10 mg twice daily with initial short course of nimesulide.  Clinical and electrophysiological reassessment was done after 6 weeks. 

RESULTS: Mean age was 43.9 years with male to female ratio of 1:2.33. Sixty five percent cases showed significant clinical improvement which was supported by significant improvement in electrophysiological parameters. Recurrence was reported in four cases. No significant side effect was observed. 

CONCLUSIONS: serrapeptase therapy may proved to be a useful alternative mode of conservative treatment.  Larger study may be further helpful to establish the role of serrapeptase in CTS.